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Remarkably, KDS12025 demonstrated significant efficacy in mitigating RA pathology, as evidenced by a reduction in the CIA score, a clinical measure of joint inflammation severity, and improvements in histological parameters, including synovial hyperplasia and cartilage destruction, as shown via H&E and toluidine blue staining (Supplementary Fig

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Further oxidation of a disulfide yields a thiosulfonate (Figure 5), which releases a disulfide and sulfinic acid subsequent to reaction with a thiol